Oral route is the main route of drug administration in many diseases. Major problem in oral route of drug administration is bioavailability which mainly results from poor aqueous solubility. This leads to lack of dose uniformity and high intrasubject/intersubject variability. It is found that 40% of active substances are poorly water-soluble. Various technologies are developed to overcome this problem, like solid dispersion or cyclodextrin complex formation. Much attention has been given to Self-Micro Emulsifying Drug Delivery System (SMEDDS). SMEDDS appears to be a unique and industrially feasible approach to overcome the problem of low oral bioavailability associated with the lipophillic drugs. It requires small amount of dose and also drugs can be protected from hostile environment in gut. The digestive motility of the stomach and intestine provide the agitation necessary for self-emulsification in vivo. Self micro emulsifying drug delivery systems are specialized form of delivery system in which drug is encapsulated in a lipid base with or without pharmaceutical acceptable surfactant. This review describes SMEDDS as one of the important approaches to overcome the formulation difficulties of potent poorly water soluble drugs.
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